Damage Control Broccoli Seed Extract

Discussion

Sulforaphane, a naturally-occurring compound in broccoli that possesses antioxidant activity, was identifi ed in 1992 by scientists at Johns Hopkins University School of Medicine. This isothiocyanate appeared to be responsible for the apparent correlation between diets rich in cruciferous vegetables and a lower incidence of cancer. Scientists subsequently determined that the compound present in the broccoli plant is the glucosinolate precursor of sulforaphane, known as "glucoraphanin" or "SGS™."[1]

In 1997, this research group demonstrated that the SGS content of mature broccoli is highly variable and that SGS is present at much higher concentrations in broccoli seeds and three-day-old broccoli sprouts.[3] Specifi cally, the SGS content in 200 mg of broccoli seed extract or one ounce of broccoli sprouts is equivalent to the amount present in 20 oz. of market-stage broccoli.[2] Advanced, patented technology now enables 100 mgs of SGS, the equivalent of approximately 3 3/4 pounds of broccoli, to be includied in a single capsule of Damage control.

Since 1992, SGS has been studied extensively at Johns Hopkins and other prestigious medical institutions around the globe, resulting in more than 400 published studies that support this natural phytochemical's potential to achieve early protection against cell damage.

What Does SGS Do?
SGS is multidimensional, one of its primary actions being the activation of transcription factor, Nrf2, which induces increased production of phase 2 detoxifying enzymes and antioxidant enzymes. These enzymes generally last 72 hours or more, signifi cantly longer than direct antioxidants such as vitamins C and E and beta carotene. [3-6] In addition, SGS supports cell cycle arrest and cell suicide in cells that have the potential to mutate.[3,7,8,9] It also provides support for the body's protective response against harmful microbes[10,11] and its protective response against age-related CNS infl ammation.[12] Additionally, SGS supports eye[13] and cardiovascular health.[14,15]

Dosing

Take one capsule twice daily

or as directed by your healthcare practitioner.

Cautions

Keep out of reach of children.

References

1. Zhang Y, Talalay P, Cho CG, Posner G. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 1992; Mar 89:2399-403 [PMID: 1549603]
2. Fact Sheet, Brassica Protection Products LLC Baltimore, MD
3. Cheung KL, Kong AN. Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 2010 Mar;12(1):87-97. [PMID: 20013083]
4. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94:10367-72. [PMID: 9294217]
5. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8. [PMID: 11352861]
6. Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:11149-51 [review]. [PMID: 9326574]
7. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of Sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 1994; Apr;91:3147-3150. [PMID: 8159717]
8. Ho E, Clarke JD, Dashwood RH. Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr. 2009 Dec;139(12):2393-6 [PMID: 19812222]
9. Chu WF, Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol. 2009 Nov;45(11):998-1004. [PMID: 19589718]
10. Yanaka A, Fahey JW, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60 [PMID: 19349290]
11. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 2002 May 28;99(11):7610- [PMID: 12032331]
12. Noyan-Ashraf MH, Dietary approach to decrease aging-related CNS infl ammation. Nutr Neurosci. 2005 Apr;8(2):101-10. [PMID: 16053242]
13. Gao X, Talalay P. Induction of Phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage . Proc Natl Acad Sci USA 2004 July 101 (28): 10446-10451
14. Wu L, et al. Dietary approach to attenuate oxidative stress, hypertension, and infl ammation on the cardiovascular system. Proc Natl Acad Sci U S A.2004, May 101(18):7094-7099 [PMID: 15103025]
15. Zakkar M, et al. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinfl ammatory state. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1851-7 [PMID: 19729611]

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