Collagenesis Information

Discussion

Silica exists in a variety of forms in nature and its component, silicon is the second most prevalent element after oxygen. [1] Orthosilicic acid, (H4SiO4) a water-soluble form of silicic acid found in very dilute concentration in the earth's waters, is the form humans predominantly absorb and is found in the serum fraction of blood. In its non-polymerized form, silicon is very unstable; thus making it available for supplementation has been diffi cult. However, collagenesis's patented processing prohibits silica from turning into a polymer as silica does in other supplements (i.e. gels, horsetail herb), rendering superior absorption. Choline, a nutrient especially important to membrane health, is combined with elemental silicon to yield the stabilized form of silica in collagenesis.

Compelling data supports a myriad of health benefits of adequate silica. The benefits are undoubtedly due to silica's ability to activate the body's synthesis of collagen which constitutes one-third of the body's protein. A study demonstrated a 12.5% increase in collagen in the dermis with ch-OSA supplementation.[2] Silica supplementation stimulates collage type- 1 synthesis in osteoblasts, enhances osteoblast differentiation,[3] increases calcium uptake[4] and is a major determinant in bone mineral density in men and pre-menopausal women.[5] In addition to collagen, silica has a role in the synthesis of two other "beauty proteins" - elastin and keratin.[2] Silica defi ciency may cause bone and joint deformities and disrupt mineral balance.[1]

Another 20-week, randomized, double blind, placebo-controlled study with 50 women with photodamaged facial skin showed oral intake of 10 mg ch-OSA resulted in a 30% reduction in micro-wrinkle depth and 30% reduction in skin roughness and a positive effect on brittleness of hair and nails.[6]

In a nine-month, randomized, double-blind, placebo-controlled trial with 48 healthy Caucasian women with fine hair (average age 43.3 years), an international research team concluded that ch-OSA (5 mg ch- OSA b.i.d) safely and signifi cantly improved hair fiber thickness and helped reduce loss of hair elasticity and strength. Orthosilicic acid delivered by ch-OSA is known to bind with positively charged aminogroups in peptides. This structural interaction might improve the mechanical properties of keratin resulting in improved hair tensile properties.[7]

Dosing

Take 1 capsule two times per day or as directed by your qualified healthcare practitioner.

Other Ingredients: Microcrystalline cellulose, HPMC (vegetable capsules) and purified water.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating. This product does not contain wheat, gluten, soy, dairy, egg, fish/shellfish or nuts/tree nuts.
MADE IN BELGIUM
© 2009 Bio Minerals n.v.

References

1. Martin KR. The chemistry of silica and its potential health benefits. J Nutr Health Aging. 2007 Mar-Apr; 11(2): 94-7. [PMID: 17435951]
2. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997 Feb;56(2):153-65 [PMID: 9164661]
3. Reffi tt DM, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003 Feb;32(2):127-35 [PMID: 12633784]
4. Calcif Tissue Int 2002;70:292, P-139
5. Jugdaohsingh R, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. Bone 2003 May;32,:S192 [PMID: 14969400]
6. Barel A, et al. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res. 2006 Feb;297(8):381 [PMID: 16205932]
7. Wickett RR, Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fi ne hair. Arch Dermatol Res. 2007 Dec;299(10):499-505. [PMID: 17960402]
8. Silicon: http://nhiondemand.com {accessed 18 Dec 2008}

Cautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

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