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Beauty Sleep

Magnolia
officianalis and
Ziziphus spinosa


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®Genetiskin Beauty Sleep

Discussion

Two open studies with beauty sleep have been completed by an independent research fi rm in NY.[2] In the fi rst study, the 23 subjects who took the supplement as directed (at least seven capsules during the two-week period) reported the following results:

  • 83% said beauty sleep helps insure a sound night's sleep
  • 87% said beauty sleep reduces fatigue due to lack of sleep
  • 87% said beauty sleep allows you to wake up feeling refreshed

In a second study completed in March, 2005, 45 adults who were prescreened for frequency of sleeplessness in the past 2 months took 1 beauty sleep capsule at bedtime at least seven nights during a two-week period. Below are the results oftheir responses.[3]

  • 91% said beauty sleep helps insure a sound night's sleep
  • 89% said beauty sleep allows you to wake up feeling refreshed
  • 91% said beauty sleep reduces fatigue due to lack of sleep
  • 96% said beauty sleep is gentle on your stomach
  • 87% said beauty sleep has fewer side effects than other sleep aids
  • 84% said beauty sleep gives you more energy during the day

Eighty-two percent (82%) rated the product as "effective" in helping them fall asleep and eighty-seven percent (87%) of the subjects reported that they fell asleep quickly.

Magnolia officinalis (Magnolia bark), known as houpu or hou po in Traditional Chinese Medicine, has been used for thousands of years to treat "stagnation of qi", or low energy, anxiety, nervous disturbances and other maladies. It has also been popular in Japanese Kampo medicine for hundreds of years for a wide variety of clinical disorders.[4]

Magnolia bark is rich in a biphenol compound called honokiol and its isomer, magnolol. Honokiol and magnolol were identified as the anxiolytic (anxiety-reducing) agents in extracts of a Kampo medicine called Saiboku-tu.[5] After seven days of administration even at low doses the stress-reducing effect of honokiol was equivalent to that of diazepam and had lower risk for the side effects of the drug.[6]

Studies have identified the various mechanisms of action of magnolia bark extract and confirmed the effect upon the central nervous system and muscle relaxant effects. Animal studies demonstrated that one of its ingredients binds to adenosine A(1) and GABA(A) receptors associated with drowsiness.[7]

Nine other beneficial pharmacological effects of honokiol cited from other studies include: antioxidant, antiplatelet aggregation, antibacterial, antifungal, inhibition of cancer cell growth, anti-allergic and anti-inflammatory. However, beauty sleep was not designed with these actions in mind and no claims are made.

Ziziphus spinosa is a traditional plant used as a sedative in traditional Chinese medicine for more than 2000 years. Both the leaves and seeds of the plant inhibit central nervous system function, while the fruits may prolong sleep when combined with a sleep aid.[8] Sansohnin, the main component of Sansohnin-to, a traditional Chinese combination for sleeplessness is prepared from the seeds of Ziziphus spinosa.

facts

Dosing

Take 1-2 capsules nightly,

or as directed by your healthcare practitioner.

References

1.Vorona RD, Winn MO, Babineau MD, Eng, BP, Feldman HR, Ware, JC. Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index. Arch Intern Med. 2005; 165: 25-30
2. TRG Study#82-04133, Target Research Group, Inc. Nanuet, NY, August, 2004
3. TRG Study#82-05013, Target Research Group, Inc. Nanuet, NY, March, 2005
4. Hosoya E, Yamamura Y, eds. Recent advances in pharmacology of Kampo ( Japanese Herbal) Medicines: International Congress Series 85. Amsterdam, 1998 [Maruyama, Y, Kuribara H. Overview of the pharmacological features of Honokiol. CNS Drug Reviews, 2000, 6(1) 35-44]
5. Maruyama, Y, Kuribara H. Overview of the pharmacological features of Honokiol. CNS Drug Reviews, 2000, 6(1) 35-44
6. Kuribara H, Stavinoha WB, Maruyama Y. Behavioral pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of magnolia bark, evaluated plus-maze test in mice. J Pharm Pharmacol 1998;50:819-826. [Maruyama, Y, Kuribara H. Overview of the pharmacological features of Honokiol. CNS Drug Reviews,2000, 6(1) 35-44]
7. Squires R F, Ai J, Wit MR, Kahnberg P, Saederup E, Sterner O, Nielsen M. Honokiol and magnolol increase the number of [3H]Muscimol Binding sites three-fold in rat forebrain membranes in vitro using a filtrationassay, by allosterically increasing the affinities of low affinity sites. Neurochemical Research 24(12), 1999: 1593-1602
8. Wu SX, Zhang JX, Xu T, Li LF, Zhao SY, Lan MY. [Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function] Zhongguo Zhong Yao Za Zhi. 1993 Nov; 18(11):685-7, 703-4 [PMID: 8003232]

Cautions

Do not take if pregnant or lactating. Do not take if currently taking any prescription medication or receiving medical treatment without consulting your physician. Keep out of reach of children.

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

Beauty Sleep pdf here